6/17/2023 0 Comments Toad trial versionThe TOAD trial found an overall survival benefit associated with immediate ADT. The Timing Of Androgen Deprivation trial (ie, TOAD) was a randomized clinical trial seeking to address this issue by comparing the effect of immediate vs delayed ADT on overall survival, primarily among men with PSA relapse ( 3). Since the benefit of early ADT is not clear, treatment should be individualized until definitive studies are done” ( 1). For example, the 2021 National Comprehensive Cancer Network Prostate Cancer guidelines state: “Earlier ADT may be better than delayed ADT. However, when to start ADT after PSA relapse remains unclear. ![]() ![]() Androgen deprivation therapy (ADT) is a mainstay of treatment for men with prostate-specific antigen (PSA) relapse after curative therapy ( 1, 2).
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